They can overlap, and it is worth taking both seriously. Depression tends to present as a persistent low mood, a loss of interest in most activities, difficulty functioning, and a sense of hopelessness that doesn’t lift. Midlife crisis tends to present as restlessness, questioning, a search for something — energy that has lost its direction rather than energy that has gone. A man in midlife often still feels things acutely, still has moments of aliveness, still functions. If low mood is persistent, pervasive, and accompanied by difficulty sleeping, eating, or carrying out daily life, a conversation with a mental health professional is the right first step.